Valsts pētījumu programmas projekts biomedicīnā, medicīnas tehnoloģijās un farmācijā

Pētniecības projekta numurs

VPP-EM-BIOMEDICINA-2022/1-0001

Pētniecības projekta nosaukums

Valsts pētījumu programmas projekts biomedicīnā, medicīnas tehnoloģijās un farmācijā

Zinātnes nozare (pamata)

 Medicīnas bāzes zinātnes, tai skaitā farmācija

Projekta iesniedzējs

Latvijas Organiskās sintēzes institūts

Rezultāta veids

Rezultāta izpilde

Oriģināli zinātniskie raksti, kas publicēti žurnālos vai konferenču rakstu krājumos, kuru citēšanas indekss sasniedz vismaz 50 procentus no nozares vidējā citēšanas indeksa

1. Kistkins S.; Mihailovs T.; Lobanovs S.; Pīrāgs V.; Sourij H.; Moser O.; Bļizņuks D. Comparative Analysis of Predictive Interstitial Glucose Level Classification Models.. - Sensors / MDPI, 2023, https://doi.org/10.3390/s23198269
2. Fedorenko D.; Podjava A.; Prikulis A.; Bartkevics V. Dilute-and-shoot approach for determination of several biomarkers and pharmaceuticals in wastewater using nanoflow liquid chromatography – Orbitrap mass spectrometry. - Journal of Separation Science, 2023, https://doi.org/10.1002/jssc.202201002
3. Bobileva O.; Bobrovs R.; Sirma E.E.; Kanepe I.; Bula A.L.; Patetko L.; Ramata-Stunda A.; Grinberga S.; Jirgensons A.; Jaudzems K. 3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors. - Molecules, 2023, https://doi.org/10.3390/molecules28020768
4. Demir O.; Pylostomou A.; Loca D. Octacalcium Phosphate Phase Forming Cements as an Injectable Bone Substitute Materials: Preparation and In vitro Structural Study.. - Biomaterials Advances, 2023, https://doi.org/10.1016/j.bioadv.2023.213731
5. Kalnins G.; Rudusa L.; Bula A.; Zelencova-Gopejenko D.; Bobileva O.; Sisovs M.; Tars K.; Jirgensons A.; Jaudzems K.; Bobrovs R. Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors. - ChemMedChem, 2024, , https://doi.org/10.1002/cmdc.202400618
6. Sondore D.; Briede I.; Linde M.; Trusinskis K.; Narbute I.; Jegere S.; Lismanis A.; Kumsars I.; Grikis K.; Strazdins U.; Erglis A. Bioresorbable Scaffold Use in Coronary Chronic Total Occlusions: A Long-Term, Single-Center Follow-Up Study . - Medicina 2024, 60, 1233.  , 2024, , https://doi.org/10.3390/medicina60081233
7. Kistkins S.; Moser O.; Ankudovičs V.; Blizņuks D.; Mihailovs T.; Lobanovs S.; Sourij H.; Pfeiffer AFH.; Pīrāgs V. From classical dualistic antagonism to hormone synergy: potential of overlapping
   action of glucagon, insulin and GLP-1 for the treatment of diabesity. - Endocrine connections, 2024, , https://doi.org/doi: 10.1530/EC-23-0529. PMID: 38579770; PMCID: PMC11046332.
8. Liekniņa I.; Reimer L. ... Tārs K. Structural basis of epitope recognition by anti-alpha-synuclein antibodies MJFR14-6-4-2. - npj Parkinson's disease, 2024, https://doi.org/10.1038/s41531-024-00822-y
9. Kitoka K.; Lends A.; ...  Jaudzems K. dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy-Like Tau Filaments. - Angewandte Chemie International Edition, 2024 https://doi.org/10.1002/anie.202407821
10. Fan J.; Schiemer T.; ... Klavins K. Exploring the Impact of Calcium Phosphate Biomaterials on Cellular Metabolism. - Heliyon, 2024, https://doi.org/10.1016/j.heliyon.2024.e39753
11. Luginina J.; Kroskins V.. Turks M. Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates. - Scientific Reports, 2024 , https://doi.org/10.1038/s41598-024-76816-w
12. Fan J.; Schiemer T.; Vaska A.; Jahed V.; Klavins K. Cell Via Cell Viability Assay Changes Cellular Metabolic Character-istics by Intervening with Glycolysis and Pentose Phosphate Pathway. - Chemical research in toxicology, 2023, https://doi.org/10.1021/acs.chemrestox.3c00339
13. Similie D.; Minda D.; Bora L.; Kroškins V.; Lugiņina J.; Turks M.; Dehelean C.A.; Danciu C. An Update on Pentacyclic Triterpenoids Ursolic and Oleanolic Acids and Related Derivatives as Anticancer Candidates. - Antioxidants, 2024, , https://doi.org/10.3390/antiox13080952
14. Demir O.;Oselska E.; Bertins M.;Viksna A.; Boccaccini A.R. Loca D. Optimizing α-tricalcium phosphate bone cement composite formulations: The critical role of bioactive glass particle size.. - Materials & Design, 2024,https://doi.org/10.1016/j.matdes.2024.113463
15. Terentjeva M.; Ķibilds J.; Avsejenko J.; Cīrulis A.; Labecka L.; Bērziņš A. Antimicrobial Resistance in Enterococcus spp. Isolates from Red Foxes (Vulpes vulpes) in Latvia. - Antibiotics, 2024, https://doi.org/10.3390/antibiotics13020114
16. Tomsone LE.; Neilands R.; Kokina K.; Bartkevics V.; Pugajeva I. Pharmaceutical and Recreational Drug Usage Patterns during and Post COVID-19 Determined by Wastewater-Based Epidemiology. - International Journal of Environmental Research and Public Health, 2024, https://doi.org/10.3390/ijerph21020206
17. Svanberga K.; Avsejenko J.; Fridmanis D.; Kazaka T.; Berzins A.; Dislers A.; Zrelovs N. Isolation and Characterization of a Novel Aeromonas salmonicida-Infecting Studiervirinae Bacteriophage, JELG-KS1. - Microorganisms, 2024, https://doi.org/10.3390/microorganisms12030542
18. Ērika Bitiņa-Barlote Ē.; Bliznuks D.; Siliņa S.; Satcs M.; Vjaters E.; Lietuvietis V..  Liquid Biopsy Based Bladder Cancer Diagnostic by Machine Learning. - Diagnostics, 2025, https://doi.org/10.3390/diagnostics15040492
19. Pilipenko V.; Lieknina I.; Skrastina D.; Aktas S.; Revina B.L.;Upite J.;Jansone B.;Tars K. Active Immunization with Bacteriophage AP205 VLPs Results in Reduced Amyloid Load and Microgliosis in 5xFAD Female Mice. - Journal of Alzheimer's disease, 2025, https://doi.org/10.1007/s00210-025-04739-y
20. Pegoraro C.; Karpova E.; Vicent M.J. Polyproline-polyornithine diblock Copolymers with Inherent Mitochondria Tropism. - Advanced Materials, 2025, https://doi.org/10.1002/adma.202411595
21. Dimitrijevs P. Total cardiolipin levels in gastric and colon cancer: evaluating the prognostic potential. - Lipids in Health and disease, 2024,

https://doi.org/10.1186/s12944-025-02499-5

22. Mutere, O.; Gudrā, D. et al. Impact of Anthropogenic Activities on Microbial Community Structure in Riverbed Sediments of East Kazakhstan. - Microorganisms, 2025, https://doi.org/10.3390/microorganisms12020246
23. Dejus, B.; Gudra, D.; Dejus, S.; Ozols, R.; u.c.  Examining the Impact of Different Scales on COVID-19 Monitoring in Sewerage Catchment Areas: Insights from Latvia. - Journal of Hazardous Materials Advances, 2025, https://doi.org/10.1016/j.hazadv.2025.100676
24. Dejus, B.; Dumpis, U.; Strods, M. u.c. Effect of UVA/UVC-Activated TiO2 Coating on Sinks’ Pipeline System to Control Biofilm at ICU: A Case Study from Latvia. - Journal of Water Process Engineering, 2025, ttps://doi.org/10.1016/j.jwpe.2025.107655

Oriģināli zinātniskie raksti, kas iesniegti vai pieņemti publicēšanai Web of Science Core Collection vai SCOPUS datubāzēs iekļautajos žurnālos vai konferenču rakstu krājumos

1. Fedorenko D.; Podjava A.; Prikulis A.; Bartkevics V. Dilute-and-shoot approach for determination of several biomarkers and pharmaceuticals in wastewater using nanoflow liquid chromatography – Orbitrap mass spectrometry. - Journal of Separation Science, 2023, https://doi.org/10.1002/jssc.202201002

Datu bāzes, datu kopas

1. Pugajeva I.; Bartkevičs V. Datu kopa par farmaceitisko savienojumu saturu (emisiju) Rīgas notekūdeņos 2023. gadā. - 2023, https://files.fm/u/zpyrc6e79k
2. O. Kolesova, A. Vilmane, A. Kolesovs, Z. Nora-Krūkle, G. Karelis Markers of immune activation in patients with multiple sclerosis. – 2024 https://doi.org/10.48510/FK2/UWN5EV
3. Gardovskis J.; Daneberga Z.; Vjaters E.; Šatcs M. miRNA biomarkers in bladder cancer. - 2024, https://doi.org/10.48510/FK2/LZXMXB
4. Tomsone L.E.; Neilands R.; Kokina K.; Bartkevics V.; Pugajeva I. Concentrations and corresponding consumptions of the detected antibiotic compounds in tested wastewater samples. – 2024, https://doi.org/10.3390/ijerph21020206
5. Terentjeva M.; Ķibilds J.; Avsejenko J.; Cīrulis A.; Labecka L.; Bērziņš A. ARGs targeted according to AMRFinderPlus (3.11.2), with the database version 2023-08-08.2.. -2024,10.3390/antibiotics13020114

Reģistrēts II (patenti…) - starptautiski, ārvalstu

1. Vitkovska V.; Kazak M.; Suna E. Makrocikliskie tubulīna polimerizācijas inhibitori kā pretvēža līdzekļi. - 2024, PCT/IB2024/059899, Oct. 10, 2024.

Reģistrēts II (patenti…) - Latvija

1. Lugiņina J.; Kroškins V.; Lācis R.; Fedorovska E.; Turks M. Ūdenī šķīstoši triterpenoīdu fosfonāti un to iegūšanas paņēmiens, 2024, LVP2023000117
2. Vitkovska V.; Kazak M.; Sūna E. Makrocikliskie tubulīna polimerizācijas inhibitori kā pretvēža līdzekļi. - 2023, LVP2023000126

3. Kalniņš G.; Šmits G.; Jirgensons A.; Sakaine G.; Ūdris N.; Bobrovs R. Triazola-adenozīna analogi kā SAM atkarīgu metilējošo enzīmu inhibitori. - 2024, LVP2024000073 (application date 29.11.2024.) 20.11.2025. starp apstiprinātajiem patentiem nav atrodams, bet ir iesniegts.

Jauns produkts, tehnoloģija

1. Lugiņina J.; Kroškins V.; Lācis R.; Fedorovska E.; Turks M.  Ūdenī šķīstoši triterpenoīdu fosfonāti un to iegūšanas paņēmiens. - Published LV patent application, 2024, LV15836A
2. Bagante I. 3D-PRINTED ANATOMICAL MODELS FOR ORBITAL FLOOR FRACTURE TREATMENT. - Method description, 2024,
3. Klavins K.; Matusevica N.G.; Vaska A.; Lejniece K. METABOLITE EXTRACTION FROM CELLS GROWN ON BIOCERAMICS. - Method description, 2024
4. Loca D.; Demir O.; Oselska E. TECHNOLOGY DESCRIPTION: PREPARATION OF NEW CALCIUM PHOSPHATE BONE CEMENTS. - Technology description, 2024.
5. Vitkovska V.; Kazak M.; Suna E. Makrocikliskie tubulīna polimerizācijas inhibitori kā pretvēža līdzekļi. - 2024, PCT/IB2024/059899, Oct. 10, 2024.
6. Strods M.; ….Juhna T. Izlietnes tehnoloģijas izstrāde mikroorganismu vairošanās, bioplēvju veidošanās, kā arī mikroorganismu nokļūšanas slimnīcas telpās novēršanai. - 2024, Patenta pieteikums Nr. LVP2024000071
7.  Mutere O.; Blumfelde M. Disinfection of activated sludge by the Fenton and Fenton-like processes. -, 2024, BB_BIOMEDICINA_summary_Sludge treatment by Fenton Dec 03 2024.doc
   BB_IPSO20241210114904KMT10466.pdf
8. Zrelovs Ņ. Bakteriofāgu kokteiļa prototips cīņai ar Aeromonas salmonicida infekcijām zivju akvakultrās.  APLIECINAJUMS_BIOMEDICINA_WP3.edoc
9. Reščenko,R.; Silamiķelis, I.; Kampars, J.; Kloviņs, J. "Workflow for Polygenic Score Analysis and Visualization from Single-Sample Whole Genome Sequencing VCF Data". - Scientific Reports
10. Zajakina, A.; Rudevica, Z.; Korotkaja, K.; Sūna, E.; Vitkovska, V.; Kazaks,M. 3D-Spheroid Cell Model for Analysis of Anti-cancer Drugs: Assessment of Spheroid Formation, Growth, and Cell Migration.
11. Linē, A.; Zajakina, A.; Brokāne, A.; Rudeviča, Ž.; Leja, M. EV-Inducible Cell Reporter System for Colorectal Cancer Diagnostics. - Registered as technology at BMC, EVReporter technology
    APLIECINAJUMS_BIOMEDICINA_WP7.edoc
12. Gardovskis, J.; Daneberga, Z.; Vjaters, E.; Lietuvietis, V.; Bļizņuks, D. .. Non-invasive device for diagnostic of bladder cancer. - , , Registered as method description at RSU, Medicīnas tehnoloģija_in vitro diagnostikas metode_kopsavilkums_urīnpūšļa vēža diagnostika.edoc
    BIOMEDICINA_summary_final.pdf
13. Kalniņš G.; Šmits G.; Jirgensons A.; Sakaine G.; Ūdris N.; Bobrovs R. Triazola-adenozīna analogi kā SAM atkarīgu metilējošo enzīmu inhibitori. 2024, LVP2024000073 (application date 29.11.2024.)

Ārstniecības un diagnostikas metode

1. Fedorenko D.; Podjava A.; Prikulis A.; Bartkevics V. Method for the determination of population and lifestyle biomarkers and pharmaceuticals in wastewater using dilute-and shoot approach combined with nanoflow liquid chromatography – Orbitrap mass spectrometry. 2024, https://1drv.ms/w/s!ApEF49yX4Brigc8ukSpwFRYpiktzkg?e=yhQMsL

2. Tomsone LE.; Neilands R.; Kokina K.; Bartkevics V.; Pugajeva I. Data-Driven Algorithm for Seasonal and Pandemic-Responsive Monitoring of Pharmaceutical and Recreational Drug Usage via Wastewater-Based Epidemiology. - 2024, https://1drv.ms/w/s!ApEF49yX4Brigc8tGVJMwioWCcgVtg?e=ll8OjP
3. Sniedze D.; Salputra E.; Valaine K.; Allemane D.; Fainveice E. Antibakteriālās terapijas rekomendācijas vēlīnas neonatālas sepses gadījumā. - 2024

Noteiktā kārtībā aizstāvēts promocijas darbs

1. Fedorenko D. Nanoplūsmas šķidruma hromatogrāfijas un masspektrometrijas metožu izstrāde un pielietošana ķīmisko piesārņotāju noteikšanai pārtikā un vidē, 2024, https://kopkatalogs.lv/F/?func=direct&local_base=LNC04&doc_number=001167511
2. Dimitrijevs P. Izoselenazolija sāļu ietekme uz vēža metabolismu. - 2024
3. Vitkovska V. Vienkāršoti diazonamīda A analogi kā pretvēža līdzekļi. - 2024
4. Žorža L. Exploring the potential of enrichment and stimulation of biofilms derived from different sources/ Dažādas izcelsmes mikroorganismu bioplēves bagātināšanas un aktivitātes stimulēšanas iespējas. – 2024 https://dspace.lu.lv/handle/7/65569
5. Kroškins V. C-H FUNCTIONALIZATION AND SYNTHESIS OF WATER-SOLUBLE PENTACYCLIC TRITERPENOIDS . – 2025 (Mainīts promocijas darba nosaukums)